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BMC Cancer (2021) 21(1):1343

FIGURE 9 Discussion Ulcerative colitis (UC) is a chronic non-specific inflammatory bowel disease characterized by a complex pathogenesis involving multiple interrelated processes, including intestinal barrier disruption, oxidative stress imbalance, excessive inflammatory activation, gut microbiota dysbiosis, and metabolic disturbances ( Body weight loss, colon shortening, and histological damage are hallmark pathological features of the DSS-induced UC model and serve as key metrics for evaluating therapeutic interventions

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When intestinal microecology is disrupted, LPS enters blood circulation, activates the Toll-like receptor 4 (TLR4) signaling, and upregulates the expression of the NF-B pathway, which in turn promotes the differentiation and activity of osteoclasts, leading to severe bone loss and osteoporosis (62)

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